Retatrutide
The triple GLP-1/GIP/glucagon agonist — the most pronounced weight loss of its class.
iThe essentials in 10 seconds
- Most potent molecule in its class: acts on 3 receptors (GLP-1, GIP, glucagon)
- Greatest weight loss among current treatments (up to 24% in trials)
- Subcutaneous injection, once weekly, with gradual dose escalation
- Mandatory medical follow-up (digestive tolerance, pancreas, gallbladder)
IWhat is Retatrutide?
Retatrutide mimics three natural hormones involved in satiety and metabolism: GLP-1 and GIP (which suppress appetite and slow digestion) and glucagon (which increases energy expenditure). This triple action makes it more effective than single agonists. It is undergoing advanced clinical evaluation for obesity.
Recent treatment, data still maturing. Reserved for strict prescription and medical follow-up — never for self-medication.
IIThe benefits
Major reduction in appetite and caloric intake: the greatest weight loss in the class (up to ~24%).
Slows gastric emptying and acts on hunger centers: rapid and lasting feeling of fullness.
Strongly improves insulin sensitivity — major benefit in type 2 diabetes and prediabetes.
Glucagon action increases energy expenditure at rest (unlike GLP-1 agonists alone).
Reduces liver fat and lipid profile — useful in steatosis (fatty liver).
Improvement in blood pressure, triglycerides, and inflammation — targets of metabolic syndrome.
IIIRecommendations & how to use
Route: subcutaneous injection (abdomen/thigh), once weekly, preferably the same day · Escalation: start low and increase gradually to limit digestive effects · Storage: refrigerated (2–8 °C).
Treatment requires medical follow-up (tolerance, hydration, protein intake).
| Dosage | Euro | Dollar | Dirham |
|---|---|---|---|
| 10 mg | 60 € | 65 $ | 650 DH |
| 15 mg | 78 € | 85 $ | 850 DH |
Indicative exchange rates — final price confirmed during consultation.
IVThe two protocols
Goal: achieve lasting weight loss by increasing doses in steps, to minimize digestive effects.
Follow-up: weight, waist circumference, digestive tolerance, labs (blood glucose, lipids, liver).
Goal: preserve muscle mass during weight loss.
The peptide does not excuse lifestyle habits: it facilitates them.
VProtocol rules
- Sufficient protein intake to preserve muscle
- Drink regularly — hydration limits digestive effects
- Fiber-rich diet, smaller and more frequent meals
- Regular physical activity (walking + strength training)
- Record weight, tolerance, and satiety for follow-up
- Never self-medicate: medication requiring strict medical follow-up
- Do not exceed the dose or accelerate escalation
- Eating fatty/fried foods or overeating: triggers nausea and vomiting
- Excessive alcohol (pancreas, liver)
- Pregnancy, breastfeeding, history of pancreatitis or medullary thyroid cancer: contraindication
VIYour journey in 3 steps
Metabolic evaluation, contraindications, weight goals, injection training.
Stepwise increase every 4 weeks, according to tolerance and results.
Weight, body composition, labs — decision on next phase.