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GHK-Cu

skin & hair protocol
Repair & performance · Skin & hair

Copper peptide: collagen, healing, skin and hair.

iThe essentials in 10 seconds

  • Copper peptide naturally present in plasma and saliva
  • Stimulates collagen and elastin: firmness, healing, hair
  • As an injector pen (subcutaneous, fixed dose) — or topical application (cream, serum)
  • Reference peptide for regenerative skin care

IWhat is GHK-Cu?

GHK-CuThe skin peptide

GHK-Cu is a small copper-bound peptide, naturally present in plasma, saliva and urine. It stimulates the production of collagen and elastin, promotes healing and tissue regeneration, and has an antioxidant action. Its level decreases with age, which explains its popularity in skin and hair care.

Widely used in professional cosmetics (topical). The injectable form is given with the pen, under supervision: quality and sterility are crucial. Copper requires cycles with a break (4 to 6 weeks, then 2 to 4 weeks off).

An innovative approach, an experimental use

The molecules presented on this site are innovative and fall under experimental use. Human data remain limited: a studied mechanism or a preclinical observation is not sufficient to demonstrate a benefit. The regulatory status in Morocco is not established for most of these peptides. Any use is decided within the framework of a medical consultation, with follow-up — never alone, never without an assessment.

IIThe benefits

◆FirmnessStimulated collagen

Boosts the synthesis of collagen and elastin: firmer, denser skin.

◆HealingAccelerated repair

Accelerates skin repair and improves scar quality.

◆HairSupported follicle

Stimulates the hair follicle — relevant in hair loss and thinning.

◆AntioxidantThe skin shield

Antioxidant and anti-inflammatory action: protects the skin from oxidative stress.

◆Radiance & evennessRevived complexion

Contributes to a more even and radiant complexion (regular use).

◆RegenerationRenewed tissue

Supports tissue renewal and skin quality with age.

IIIRecommendations & how to use

How to useDosage · route · storage
Form: injector pen (prepared cartridge) or topical (cream/serum) — preparation and dilution provided during consultation

Route: superficial subcutaneous with the injector pen (32G · 4 mm needle) or topical application · Dose: 1 to 2 mg/day, fixed dose — the pen simplifies the daily routine · Frequency: daily, in cycles of 4 to 6 weeks then a 2 to 4 week break · Storage: refrigerated (2–8 °C), protected from light, 28 days after reconstitution.
Avoid contact with eyes; sun protection essential.

Prices on request
DosagePrice
100 mgProvided on request

Prices are not published online: they are provided on request, during a consultation or by telephone.

Supplied as a ready-to-use pen: fixed dose, one injection a day.
Supplied as a ready-to-use pen: fixed dose, one injection a day.

IVThe protocols

◆Skin protocolFirmness · radiance · anti-aging

Goal: improve firmness, radiance and evenness of complexion.

Regular application depending on the area (face, neck)
Frequency: daily or several times/week, over several weeks
Dedicated session possible with supportive actives (vitamin C, PDRN…)

Monitoring: before/after photos, hydration, tolerance.

◆Hair & scar protocolFollicle · repair

Goal: support the hair follicle and scar quality.

Targeted application on scalp / scar depending on the form
Frequency: regular over several weeks
Photo reassessment at mid-course

Monitoring: hair density, area appearance, tolerance.

◆GLOW protocolGHK-Cu + BPC-157 + TB-500 · skin · hair · repair

Goal: boost collagen and tissue repair in a single injection — blend GHK-Cu + BPC-157 + TB-500 (known as GLOW).

Format: ready-to-use vial — 70 mg (GHK-Cu 50 mg + BPC-157 10 mg + TB-500 10 mg, ratio 5:1:1)
Reconstitution: 3 ml bacteriostatic water = 23.3 mg/ml · dose 10 units (0.10 ml)/day ≈ 2.3 mg of blend, i.e. ≈ 1.7 mg GHK-Cu + 0.33 mg BPC-157 + 0.33 mg TB-500
Frequency: 1 subcutaneous injection/day · Cycle: 4 to 6 weeks then a 2 to 4 week break (copper requires the break)

Reference per component: GHK-Cu 1–2 mg/day, BPC-157 250–500 µg/day, TB-500 rather 2 mg ×2/week. The 5:1:1 ratio is rich in GHK-Cu: for an injury, supplement with separate TB-500. No clinical trial has evaluated the combination.

◆KLOW protocolGLOW + KPV · inflammation · skin · recovery

Goal: the same base as GLOW, reinforced with KPV (anti-inflammatory tripeptide): skin, mucous membranes and low-grade inflammation.

Format: ready-to-use vial — 80 mg (GHK-Cu 50 mg + KPV 10 mg + BPC-157 10 mg + TB-500 10 mg, ratio 5:1:1:1)
Reconstitution: 3 ml bacteriostatic water = 26.7 mg/ml · titration: weeks 1–2 = 7.5 units (≈ 2 mg), weeks 3–4 = 15 units (≈ 4 mg), weeks 5–8 = 22.5 units (≈ 6 mg), then a tapering plateau
Frequency: 1 subcutaneous injection/day · Cycle: 4 to 6 weeks (up to 8–12 weeks with slow titration) then a 2 to 4 week break

Reference per component: GHK-Cu 1–2 mg/day, KPV 300–500 µg/day, BPC-157 300–500 µg/day, TB-500 2 mg ×2/week then 2 mg/week. A blue-green line at the injection site is possible (copper, harmless). No clinical trial has evaluated the blend.

VProtocol rules

Good habits
  • Daily sun protection (SPF)
  • Regular skin hydration
  • Before/after follow-up photos
  • Consistency over several weeks
  • Store the cartridge in the refrigerator (2–8 °C)
To avoid / precautions
  • Avoid contact with eyes
  • Do not mix with irritating actives without advice
  • No use of the pen without medical training
  • Do not use on damaged or infected skin without advice
  • Known allergy to copper or peptides: medical advice

VIYour journey in 3 steps

Step 1 · Consultation
Assessment & photos

Evaluation of skin/hair, goals, reference photos, protocol provided.

Course
Pen injections & follow-up

Pen injections (or applications) depending on the area, tolerance monitoring.

Step 3 · Reassessment
Photos & adjustment

Before/after comparison, decision on continuation and associated actives.

VIISide effects & level of evidence

Level of evidenceLimited human dataMainly cosmetic topical data; injectable use very poorly documented.
Reported adverse effects
  • Redness, itching, tightness at application site
  • Skin irritation (topical)
  • Pain, bruising (injection)
  • Transient tingling
Contraindications & precautions
  • Copper or excipient allergy
  • Wilson's disease
  • Broken skin or infected wound (topical)
  • Pregnancy, breastfeeding: caution

Non-exhaustive list based on the available literature and known class effects; it replaces neither a product label nor an individual medical assessment.

VIIIPublications & references

180 publications indexed in PubMed · of which 65 with human subjects
Search on PubMed Clinical trials (ClinicalTrials.gov)

Documentary references: the existence of a publication establishes neither efficacy nor safety for personal use. The regulatory status in Morocco must be verified.

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